Diketopiperazines from marine-derived <i>Exserohilum</i> sp. M1-6
A new diketopiperazine (<b>1</b>) and 11 known compounds (<b>2-12</b>) were isolated from marine-derived <i>Exserohilum</i> sp. M1-6. The structure and the absolute configuration of compound <b>1</b> were determined by NMR, HRESIMS and electronic circular dichroism (ECD) data. The pro-angiogenic activity of compounds <b>2-12</b> were evaluated on the basis of a zebrafish model. The results showed that compounds <b>3</b>, <b>11</b> and <b>12</b> had pro-angiogenic activity at a concentration of 40 μM.
Authors
- P. Li
- C. Karen Liu (ORCID: https://orcid.org/0000-0001-5926-0905)
- Cong Wang (ORCID: https://orcid.org/0000-0002-2269-4766)
- Shengyan Zheng
- Rui Xu (ORCID: https://orcid.org/0000-0001-5158-5393)
- Shugeng Cao
- Minjun Chen
- Xuefang Yang
- Zihan Jin
- Jianjian Wang
Institutions
- Qilu University of Technology (CN)
- State Ethnic Affairs Commission (CN)
- University of Hawaii at Hilo (US)
- Shandong Academy of Sciences (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1080/14786419.2025.2610766
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00