Dunhuang Gancao Fuling Xingren decoction and its components alleviate CPT-11 induced intestinal mucositis by regulating gut microbiota related innate immunity and inflammatory response in Drosophila and mice
GFXD alleviates CPT-11-induced intestinal mucositis by modulating gut microbiota composition, suppressing JAK-STAT and Toll-Imd pathways. Thus, this study demonstrates GFXD and its bioactive constituents as novel therapeutic agents to mitigate CIM.
Authors
- J Li
- Jing He (ORCID: https://orcid.org/0000-0003-3904-8928)
- Yuyu Liu (ORCID: https://orcid.org/0000-0002-4814-8616)
- Xiaoqian Wang (ORCID: https://orcid.org/0000-0001-6433-7727)
- Yaoxing Duan
- Yujie Qin
- Minghui Xiu
- Peihao Zhang
- Xiaolin Jiang
- Jinhan Wu
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Ministry of Education (BD)
- Lanzhou University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s13020-025-01279-8
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00