Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis
Our study reveals the complex role for cDC1 with reduced Regnase-1 expression in inflammatory regulation, exacerbating inflammatory responses during the acute phase, while facilitate recovery. This dual role highlights Regnase-1 in cDC1 as a critical regulator that balances inflammation and immune memory.
Authors
- Shintaro Muraoka
- O. Takeuchi
- Masanori Yoshinaga
- Tsuneyasu Kaisho (ORCID: https://orcid.org/0000-0003-2616-1665)
- Xingyu Rong (ORCID: https://orcid.org/0000-0003-2107-8563)
- Hai Wang (ORCID: https://orcid.org/0000-0001-5911-4131)
- Takuya Uehata
Institutions
- Wakayama Medical University (JP)
- Kyoto University (JP)
- Fudan University Shanghai Cancer Center (CN)
- Kyoto College of Medical Science (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1725702
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency