Proteomic analysis confirmed that the occurrence of diabetic sarcopenia is related to autophagy and apoptosis

This study employed proteomics techniques to conduct bioinformatics analysis of DEPs in the gastrocnemius muscles of T2DM rats, as well as to explore potential pathogenic pathways. By verifying the proteins related to the pathways of autophagy and apoptosis in cells, we have, for the first time, confirmed through proteomics data that sarcopenia caused by T2DM may be associated with decreased autophagy and increased apoptosis. These research results provide rich data and theoretical basis for the diagnosis and treatment of diabetic sarcopenia.