Neuropsychological and neuroimaging characteristics of patients with mild cognitive impairment and negative-amyloid deposition

Aβ<sub>neg</sub> MCI patients who exhibit AD-like cognitive and structural abnormalities, particularly involving the hippocampus, may be associated with advanced cognitive decline or dementia progression. These results may help identify high-risk individuals within the heterogeneous Aβ<sub>neg</sub> MCI population.

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Publication Details

Journal
Frontiers in Neurology
Published
2026-01-05
DOI
https://doi.org/10.3389/fneur.2025.1658712
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Neuropsychological and neuroimaging characteristics of patients with mild cognitive impairment and negative-amyloid deposition

Kewei W. Chen, Yaojing Chen, S Zhang, Xiangwei Dai et al.
Frontiers in Neurology
Dementia and Cognitive Impairment Research
article

Neuropsychological and neuroimaging characteristics of patients with mild cognitive impairment and negative-amyloid deposition

Kewei W. Chen, Yaojing Chen, S Zhang, Xiangwei Dai, Dantao Peng, Lin Ai, Yanan Qiao, Xin Li, Junying Zhang, Zhanjun Zhang
article en

Abstract

Aβ<sub>neg</sub> MCI patients who exhibit AD-like cognitive and structural abnormalities, particularly involving the hippocampus, may be associated with advanced cognitive decline or dementia progression. These results may help identify high-risk individuals within the heterogeneous Aβ<sub>neg</sub> MCI population.

Frontiers in NeurologyVol. 16
Capital Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Beijing Normal University (CN), China-Japan Friendship Hospital (CN), Beijing Tian Tan Hospital (CN), Shandong First Medical University (CN), Banner Alzheimer’s Institute
National Natural Science Foundation of China, China Academy of Chinese Medical Sciences
Openalex Percentile: Top 96%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Neuropsychological and neuroimaging characteristics of patients with mild cognitive impairment and negative-amyloid deposition — Kewei W. Chen, Yaojing Chen, et al. · Frontiers in Neurology (2026) | TGRS Research Map | TGRS