A new SO2 probe ZSO targeting VDBP inhibits high glucose induced endothelial cell senescence and calcification

This study identifies ZSO as a novel small molecule that inhibits endothelial senescence and calcification, and establishes its role in directly targeting VDBP to promote degradation. Furthermore, our findings underscore the critical role of VDBP in vascular aging and calcification and suggest its potential utility as a biomarker for diabetic vascular complications.

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Publication Details

Journal
Frontiers in Physiology
Published
2026-01-05
DOI
https://doi.org/10.3389/fphys.2025.1719853
Primary Topic
Vitamin D Research Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

A new SO2 probe ZSO targeting VDBP inhibits high glucose induced endothelial cell senescence and calcification

Xinyu Dong, JunYing Miao, Congyao Zhao, Xiaohui Chi et al.
Frontiers in Physiology
Vitamin D Research Studies
article

A new SO2 probe ZSO targeting VDBP inhibits high glucose induced endothelial cell senescence and calcification

Xinyu Dong, JunYing Miao, Congyao Zhao, Xiaohui Chi, BaoXiang Zhao, Xuemin Yan, Zhaomin Lin
article en

Abstract

This study identifies ZSO as a novel small molecule that inhibits endothelial senescence and calcification, and establishes its role in directly targeting VDBP to promote degradation. Furthermore, our findings underscore the critical role of VDBP in vascular aging and calcification and suggest its potential utility as a biomarker for diabetic vascular complications.

Frontiers in PhysiologyVol. 16
Shandong University (CN), Second Hospital of Shandong University (CN), Shanghai Institute of Organic Chemistry (CN)
Shandong University, Natural Science Foundation of Shandong Province, State Key Laboratory of Mechanical Transmissions, National Key Research and Development Program of China
Openalex Percentile: Top 97%
Vitamin D Research Studies
DOIOpen Access PDFOpenAlex
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A new SO2 probe ZSO targeting VDBP inhibits high glucose induced endothelial cell senescence and calcification — Xinyu Dong, JunYing Miao, et al. · Frontiers in Physiology (2026) | TGRS Research Map | TGRS