Targeting BUB1B-driven cancer stemness in lung adenocarcinoma: a novel therapeutic strategy via PI3K/AKT pathway modulation
BUB1B is a pivotal regulator linking tumor stemness with malignant progression and immune context in LUAD, highlighting its potential as a diagnostic, prognostic, and therapeutic biomarker.
Authors
- Ruixue Gu (ORCID: https://orcid.org/0009-0007-4469-3047)
- Longhao Wang (ORCID: https://orcid.org/0000-0002-4642-4701)
- Lina Liu (ORCID: https://orcid.org/0000-0002-6006-0027)
- Qingyu Zhang (ORCID: https://orcid.org/0000-0001-9739-3899)
- Hehe Li (ORCID: https://orcid.org/0000-0002-5568-3975)
- Ying Xing
- Li Cai
- Ge Li
- Yan Guo
- Shundong Cang
Institutions
- Harbin Medical University (CN)
- Zhengzhou University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Shangqiu First People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Expert Opinion on Therapeutic Targets
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1080/14728222.2025.2603892
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00