The role of age-related genes in idiopathic pulmonary fibrosis and molecular docking analysis of their drug targets
Our integrative analysis reveals novel molecular connections between cellular senescence programs and fibrotic lung remodeling, positioning <i>CLU</i> and <i>LCN2</i> as pivotal regulators of age-associated pulmonary fibrosis. The identified drug candidates exhibit therapeutic potential through multi-target engagement mechanisms, providing a translational framework for developing senescence-modulating therapies in IPF.
Authors
- Wei Dong Zhang (ORCID: https://orcid.org/0000-0002-8850-5235)
- Qian Zhang
- Tingting Xia
Institutions
- First People’s Hospital of Zunyi (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1697013
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00