Integrated transcriptomic analysis and experimental validation identify ACADL as a mitochondrial tumor suppressor via the FOXO3a/PUMA axis in lung adenocarcinoma

ACADL functions as a mitochondria-associated tumor suppressor that impedes LUAD progression through activation of the FOXO3a/PUMA signaling pathway, underscoring its potential as a therapeutic target for LUAD.

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Publication Details

Journal
European journal of medical research
Published
2026-01-05
DOI
https://doi.org/10.1186/s40001-025-03559-3
Primary Topic
FOXO transcription factor regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrated transcriptomic analysis and experimental validation identify ACADL as a mitochondrial tumor suppressor via the FOXO3a/PUMA axis in lung adenocarcinoma

Yan Ding, Ying Wang
European journal of medical research
FOXO transcription factor regulation
article

Integrated transcriptomic analysis and experimental validation identify ACADL as a mitochondrial tumor suppressor via the FOXO3a/PUMA axis in lung adenocarcinoma

Yan Ding, Ying Wang
article en

Abstract

ACADL functions as a mitochondria-associated tumor suppressor that impedes LUAD progression through activation of the FOXO3a/PUMA signaling pathway, underscoring its potential as a therapeutic target for LUAD.

European journal of medical researchVol. 31(1)
First Affiliated Hospital of Gannan Medical University (CN)
Good health and well-being
Openalex Percentile: Top 97%
FOXO transcription factor regulation
DOIOpen Access PDFOpenAlex
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Integrated transcriptomic analysis and experimental validation identify ACADL as a mitochondrial tumor suppressor via the FOXO3a/PUMA axis in lung adenocarcinoma — Yan Ding, Ying Wang · European journal of medical research (2026) | TGRS Research Map | TGRS