Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation
Donor <i>HLA-G</i> 3'UTR and recipient <i>LILRB1</i>-PROMO haplotypes define a functional immunogenetic axis that differentially influence TCMR and AMR. These results support the clinical potential of HLA-G/LILRB1 genetic profiling to improve donor selection in living KTx and to guide the development of novel rejection therapies.
Authors
- Andreas Heinold (ORCID: https://orcid.org/0000-0002-6996-5156)
- F. Heinemann
- Peter A. Horn (ORCID: https://orcid.org/0000-0003-0901-3484)
- Johanna Reinold
- Sabine Schramm
- O Witzke
- Anja Gäckler (ORCID: https://orcid.org/0000-0002-3630-4386)
- Yannik Busch (ORCID: https://orcid.org/0000-0001-6261-6853)
- Julian Hölzenbein
- Benjamin Wilde
- Wolfgang Peter
- Vera Rebmann
- Hana Rohn
- Nina Gruenen
Institutions
- Steinbeis Foundation (DE)
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1697839
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00