Quantum-enabled magnetoencephalography with optically pumped magnetometers for laser-based clinical neuroimaging

Magnetoencephalography provides millisecond resolution mapping of human brain activity by measuring tiny neuromagnetic fields.Conventional systems use cryogenic superconducting sensors, which require liquid helium, rigid helmet geometry, and large shielded rooms.These constraints limit access, especially for children and patients who cannot remain still.Quantum-enabled magnetoencephalography based on laser-driven optically pumped magnetometers offers a room-temperature alternative.Circularly polarized laser light prepares and reads out spin-polarized atomic vapors that act as highly sensitive magnetic field sensors placed directly on the scalp.Wearable and on-scalp arrays improve signal strength, spatial resolution, and tolerance to movement, enabling open, naturalistic paradigms such as free reaching, walking, and social interaction.Early clinical and translational studies in epilepsy, presurgical mapping, and neurodevelopmental disorders show performance comparable to or better than conventional systems.Quantum-enabled magnetoencephalography links laser physics, quantum sensing, and clinical neurophysiology, with strong potential for adoption in broader clinical settings.