Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy
Highlighting a more favourable stromal and molecular profile after integration of high-dose SBRT to FFX, this study supports the development, rationale and validation in prospective trials of using this treatment combination in non-metastatic PDAC.
Authors
- Christelle Bouchart (ORCID: https://orcid.org/0000-0003-1714-234X)
- Vincent Detours (ORCID: https://orcid.org/0000-0002-8215-3662)
- Matthieu Hein (ORCID: https://orcid.org/0000-0003-4243-1653)
- Vjola Tafciu
- Léo Mas
- Rémy Nicolle (ORCID: https://orcid.org/0000-0001-8084-1173)
- Anaïs Boisson
- Karen Willard‐Gallo (ORCID: https://orcid.org/0000-0002-1150-1295)
- Eric Quertinmont (ORCID: https://orcid.org/0000-0002-7201-7851)
- Ellis Michiels (ORCID: https://orcid.org/0000-0003-1806-8372)
- Oier Azurmendi Senar (ORCID: https://orcid.org/0009-0004-1658-6111)
- Kosta Stosic (ORCID: https://orcid.org/0009-0005-2984-034X)
- Pieter Sp Demetter
- Jean-Luc Van Laethem
- Jean-Baptiste Bachet
- Tatjana Arsenijevic
- Shulin Zhao
- Dirk Van Gestel
- Laurine Verset
- Nicky D’Haene
- Luigi Moretti
- Julie Navez
- Ilse Rooman
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Vrije Universiteit Brussel (BE)
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Jules Bordet (BE)
- Erasmus Hospital (BE)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche sur l'Inflammation (FR)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1038/s41416-025-03274-0
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vrije Universiteit Brussel