Overactive PDGFRα and PDGFRβ promote distinct yet overlapping phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving drastic muscle growth
These findings establish PDGFRα and PDGFRβ signaling as distinct regulators of muscle remodeling and establish overactive PDGFRα as a mouse model to study skeletal muscle fibrosis in the absence of other confounding variables.
Authors
- Jordan D. Fuqua (ORCID: https://orcid.org/0000-0002-4437-0834)
- Lorin E. Olson (ORCID: https://orcid.org/0000-0003-2168-7836)
- Jacob L. Brown (ORCID: https://orcid.org/0000-0003-0912-7924)
- Hae Ryong Kwon (ORCID: https://orcid.org/0000-0002-0428-3971)
- Sandra Rigsby
- Longbiao Yao
- Frederick F. Peelor
- Szczepan Olszewski
- Benjamin F Miller
- Christiana J Raymond-Pope
- Mariola Gimla
Institutions
- Florida State University (US)
- Oklahoma Medical Research Foundation (US)
- Wisconsin Society for Cardiovascular and Pulmonary Health & Rehabilitation (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-02
- DOI
- https://doi.org/10.64898/2026.01.02.697406
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00