Morinda officinalis oligosaccharides improves sperm motility via the gut microbiota and the IGF-1/PI3K/mTOR signaling pathway

MOS ameliorates gossypol-induced asthenozoospermia by remodeling the gut microbiota and activating IGF-1/PI3K/mTOR signaling, thereby improving sperm motility and reducing apoptosis. These findings highlight MOS as a promising microbiota-modulating therapeutic strategy for male reproductive dysfunction.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-01-05
DOI
https://doi.org/10.3389/fendo.2025.1711475
Primary Topic
Research in Cotton Cultivation
Type
article
Field-Weighted Citation Impact
0.00
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article

Morinda officinalis oligosaccharides improves sperm motility via the gut microbiota and the IGF-1/PI3K/mTOR signaling pathway

Hui Lü, Yejuan Li, Anguo Wang, Guoxuan Li et al.
Frontiers in Endocrinology
Research in Cotton Cultivation
article

Morinda officinalis oligosaccharides improves sperm motility via the gut microbiota and the IGF-1/PI3K/mTOR signaling pathway

Hui Lü, Yejuan Li, Anguo Wang, Guoxuan Li, Bingxue Ouyang, Jiajia Hu
article en

Abstract

MOS ameliorates gossypol-induced asthenozoospermia by remodeling the gut microbiota and activating IGF-1/PI3K/mTOR signaling, thereby improving sperm motility and reducing apoptosis. These findings highlight MOS as a promising microbiota-modulating therapeutic strategy for male reproductive dysfunction.

Frontiers in EndocrinologyVol. 16
Hainan Modern Women and Children's Hospital (CN), Hainan Medical University (CN), University of Hong Kong (HK)
Openalex Percentile: Top 97%
Research in Cotton Cultivation
DOIOpen Access PDFOpenAlex
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Morinda officinalis oligosaccharides improves sperm motility via the gut microbiota and the IGF-1/PI3K/mTOR signaling pathway — Hui Lü, Yejuan Li, et al. · Frontiers in Endocrinology (2026) | TGRS Research Map | TGRS