Phytochemical characterization and pharmacological evaluation of aerial and root parts of Dalea pazensis Rusby [Fabaceae]
This is the first chemical report of the EO and the deepening of prenylflavonoid content in different extracts of <i>D. pazensis</i>, highlighting the pharmacological relevance of its dual antifungal and antityrosinase profile, a combination of interest for dermatological formulations targeting fungal infections, hyperpigmentation, or post-infectious dyschromias. The findings underscore this species as a promising source of prenylated flavanones with dual antifungal and anti-tyrosinase activity, as well as bioactive volatiles with antifungal activity. The results support its use in developing natural antifungal therapies, particularly against MDR pathogens.
Authors
- Javier Echeverría
- Elia Pérez Aguirre
- Mariana Andrea Peralta (ORCID: https://orcid.org/0000-0001-9362-8566)
- María Daniela Santi (ORCID: https://orcid.org/0000-0002-3866-1424)
- Melisa Fabiana Negro (ORCID: https://orcid.org/0009-0008-8145-4739)
- Maria Gabriela Ortega
Institutions
- Universidad de Santiago de Chile (CL)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Córdoba (AR)
- Max Planck Institute for Multidisciplinary Sciences (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fphar.2025.1717359
- Primary Topic
- Biological Stains and Phytochemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Nacional de Córdoba
- Consejo Nacional de Investigaciones Científicas y Técnicas