Phytochemical characterization and pharmacological evaluation of aerial and root parts of Dalea pazensis Rusby [Fabaceae]

This is the first chemical report of the EO and the deepening of prenylflavonoid content in different extracts of <i>D. pazensis</i>, highlighting the pharmacological relevance of its dual antifungal and antityrosinase profile, a combination of interest for dermatological formulations targeting fungal infections, hyperpigmentation, or post-infectious dyschromias. The findings underscore this species as a promising source of prenylated flavanones with dual antifungal and anti-tyrosinase activity, as well as bioactive volatiles with antifungal activity. The results support its use in developing natural antifungal therapies, particularly against MDR pathogens.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-05
DOI
https://doi.org/10.3389/fphar.2025.1717359
Primary Topic
Biological Stains and Phytochemicals
Type
article
Field-Weighted Citation Impact
0.00

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article

Phytochemical characterization and pharmacological evaluation of aerial and root parts of Dalea pazensis Rusby [Fabaceae]

Javier Echeverría, Elia Pérez Aguirre, Mariana Andrea Peralta, María Daniela Santi et al.
Frontiers in Pharmacology
Biological Stains and Phytochemicals
article

Phytochemical characterization and pharmacological evaluation of aerial and root parts of Dalea pazensis Rusby [Fabaceae]

Javier Echeverría, Elia Pérez Aguirre, Mariana Andrea Peralta, María Daniela Santi, Melisa Fabiana Negro, Maria Gabriela Ortega
article en

Abstract

This is the first chemical report of the EO and the deepening of prenylflavonoid content in different extracts of <i>D. pazensis</i>, highlighting the pharmacological relevance of its dual antifungal and antityrosinase profile, a combination of interest for dermatological formulations targeting fungal infections, hyperpigmentation, or post-infectious dyschromias. The findings underscore this species as a promising source of prenylated flavanones with dual antifungal and anti-tyrosinase activity, as well as bioactive volatiles with antifungal activity. The results support its use in developing natural antifungal therapies, particularly against MDR pathogens.

Frontiers in PharmacologyVol. 16
Universidad de Santiago de Chile (CL), Consejo Nacional de Investigaciones Científicas y Técnicas (AR), Universidad Nacional de Córdoba (AR), Max Planck Institute for Multidisciplinary Sciences (DE)
Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas
Openalex Percentile: Top 96%
Biological Stains and Phytochemicals
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Phytochemical characterization and pharmacological evaluation of aerial and root parts of Dalea pazensis Rusby [Fabaceae] — Javier Echeverría, Elia Pérez Aguirre, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS