Effects of GLP-1 and GIP on cholinergic-induced contractility in isolated jejunal muscle from obese patients with and without type 2 diabetes mellitus
This study demonstrates that reduced cholinergic activity in longitudinal muscle, lower GIP, and increased GLP-1 in T2DM indicate a shifted local incretin environment that may collectively suppress jejunal contractility.
Authors
- L. Kupcinskas
- Lina Jankauskaitė (ORCID: https://orcid.org/0000-0002-6997-4917)
- Mantas Malinauskas (ORCID: https://orcid.org/0000-0001-9879-3130)
- Rita Gudaitytė (ORCID: https://orcid.org/0000-0001-7489-8069)
- Kristina Rysevaite-Kyguoliene
- Almantas Maleckas (ORCID: https://orcid.org/0000-0003-1963-2190)
- Darius Stukas
- Anna Casselbrant
Institutions
- Lithuanian University of Health Sciences (LT)
- University of Gothenburg (SE)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fphys.2025.1734360
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00