Deprescribing antihypertensive medications in older people: a systematic review and a meta-analysis
The effects of deprescribing antihypertensive medications in older adults remain uncertain. The limited and low-event-rate evidence on key cardiovascular outcomes for older individuals highlights the need for individualized decision-making, especially in frail and multimorbid populations. This review provides a foundation for future research to address gaps and guide safer deprescribing practices in older adults in routine clinical practice.
Authors
- Enriqueta Vallejo‐Yagüe (ORCID: https://orcid.org/0000-0002-5911-2037)
- Carole Lunny (ORCID: https://orcid.org/0000-0002-7825-6765)
- Sven Streit (ORCID: https://orcid.org/0000-0002-3813-4616)
- Martina Zangger (ORCID: https://orcid.org/0000-0002-4278-6668)
- Carmen Floriani
- Orestis Efthimiou (ORCID: https://orcid.org/0000-0002-0955-7572)
- Prof Jacobijn Gussekloo
- Marc von Gernler
- Stella S. Daskalopoulou
- Maja Josephine Lundberg Andersen
- Giovanni Minchio
- Jens Søndergaard
- Wade Thompson
- Lisa M. McCarthy
- Carina Lundby
- Angela Edith Schulthess-Lisibach
- Rosalinde K. E. Poortvliet
- Stefan Neuner-Jehle
Institutions
- University of Bern (CH)
- University of British Columbia (CA)
- University of Southern Denmark (DK)
- University of Toronto (CA)
- University of Trento (IT)
- University of Zurich (CH)
- Leiden University Medical Center (NL)
- Trillium Health Centre (CA)
- Odense University Hospital (DK)
- McGill University Health Centre (CA)
- University Hospital of Zurich (CH)
- University of Teacher Education Lucerne (CH)
- Institute of Social and Preventive Medicine (CH)
Publication Details
- Journal
- BMC Geriatrics
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12877-025-06941-2
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00