GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis
Our study identified GRSF1 as a cell-intrinsic metabolic checkpoint that maintains cardiac BCAA homeostasis by regulating BCKDHB mRNA turnover. Targeting GRSF1 may offer therapeutic benefits for heart failure and other cardiometabolic diseases requiring BCAA manipulation.
Authors
- He Cui (ORCID: https://orcid.org/0000-0001-6277-9804)
- Chenyu Fan (ORCID: https://orcid.org/0000-0002-5405-3090)
- Mei‐Yan Xu (ORCID: https://orcid.org/0000-0002-4234-4296)
- Hu Wang (ORCID: https://orcid.org/0000-0002-0503-2365)
- Jiaxing Wang (ORCID: https://orcid.org/0000-0002-6674-4948)
- Cihang Liu
- Hui Li
- Ling Jin
- Min Zhu
- Jiangping Song
- Jichun Yang
- Wengong Wang
- Ming Cui
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Kunming Medical University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1161/circulationaha.125.074700
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 22.24