Linezolid Toxicity in South African Children With Rifampicin-resistant Tuberculosis
There is little evidence about linezolid-attributed toxicity in children with drug-resistant tuberculosis. In a prospective cohort of South African children treated with linezolid, anemia, thrombocytopenia and peripheral neuropathy were common, sometimes severe, and often required active management. Peripheral neuropathy and grade 3/4 events typically occurred after ≥3 months of treatment.
Authors
- Hendrik Simon Schaaf (ORCID: https://orcid.org/0000-0001-5755-4133)
- Sacha Horn (ORCID: https://orcid.org/0000-0001-7965-5728)
- A. C. Hesseling
- Louvina E. van der Laan
- Anthony J. Garcia-Prats
Institutions
- University of Wisconsin–Madison (US)
- Desmond Tutu HIV Foundation (ZA)
- Stellenbosch University (ZA)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1097/inf.0000000000005135
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00