Case Report: A case of lymph node metastatic cancer of unknown primary with elevated alpha-fetoprotein achieving long-term survival

This case demonstrates that for CUP confined to lymph nodes, active and precisely reasoned individualized treatment can significantly improve prognosis, even in cases categorized as having an unfavorable prognosis. Furthermore, it underscores the necessity of immunohistochemistry for the accurate diagnosis of CUP and suggests that promoting precision medicine strategies may improve outcomes for these patients.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-05
DOI
https://doi.org/10.3389/fonc.2025.1724466
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Case Report: A case of lymph node metastatic cancer of unknown primary with elevated alpha-fetoprotein achieving long-term survival

Bifei Huang, Chao-Qun Wang, Yan Wang
Frontiers in Oncology
Cancer Diagnosis and Treatment
article

Case Report: A case of lymph node metastatic cancer of unknown primary with elevated alpha-fetoprotein achieving long-term survival

Bifei Huang, Chao-Qun Wang, Yan Wang
article en

Abstract

This case demonstrates that for CUP confined to lymph nodes, active and precisely reasoned individualized treatment can significantly improve prognosis, even in cases categorized as having an unfavorable prognosis. Furthermore, it underscores the necessity of immunohistochemistry for the accurate diagnosis of CUP and suggests that promoting precision medicine strategies may improve outcomes for these patients.

Frontiers in OncologyVol. 15
Wenzhou Medical University (CN), Dongyang People's Hospital (CN)
No poverty
Openalex Percentile: Top 98%
Cancer Diagnosis and Treatment
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Case Report: A case of lymph node metastatic cancer of unknown primary with elevated alpha-fetoprotein achieving long-term survival — Bifei Huang, Chao-Qun Wang, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS