Mandibular extracellular vesicles mediate morphogenesis and mineralization of tooth germs in miniature swine through the miR-206/HDAC4 signaling axis
Our identification of the exosomal miR-206/HDAC4 signal axis redefines the mandible as an active epigenetic modulator of odontogenesis. This vesicle-mediated regulation enables long-range delivery of epigenetic effectors-revealing a paradigm shift in tooth development and a druggable target for tooth regeneration.
Authors
- Xiaoyu Cao (ORCID: https://orcid.org/0000-0003-4972-7617)
- Yiping Gao
- Xiaohong Du
- Xiaojun Sun
- Duanlin Ma
- Wen Liu
- Yujiao Song
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fcell.2025.1707072
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanxi Province