Reduced functional connectome uniqueness on the whole brain and network levels as a clinically relevant and reproducible neuroimaging marker in major depressive disorder
Reduced FC uniqueness in frontoparietal and sensorimotor networks corelate with neurobiological organization in MDD and represents a reproducible, clinically interpretable neuroimaging marker with potential utility for diagnosis and stratification.
Authors
- Hitomi Kitagawa
- Eri Itai
- Kohei Kurita
- Rio Kamashita (ORCID: https://orcid.org/0009-0004-8876-0887)
- Yusuke Sudo (ORCID: https://orcid.org/0000-0002-7648-9370)
- Yuki Ikemizu
- Toshiharu Kamishikiryo (ORCID: https://orcid.org/0000-0002-4933-0161)
- Siti Nurul Zhahara
- Koji Matsumoto (ORCID: https://orcid.org/0000-0002-9444-4512)
- Yoshiyuki Hirano (ORCID: https://orcid.org/0000-0002-9053-0595)
- Junbing He
- Y. Isobe
- Eiji Shimizu
- Go okada
- Tokiko Yoshida
Institutions
- Hiroshima University (JP)
- Chiba University (JP)
- Chiba University Hospital (JP)
- Center for Forensic Mental Health, Chiba University (JP)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1016/j.jad.2025.121073
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00