Reduced SNHG16 promotes sepsis-induced intestinal injury via the miR-15a-5p/AKT3 axis
The downregulation of SNHG16 mediated the injury effect of LPS on intestinal cells by upregulating miR-15a-5p and further targeting AKT3. SNHG16 was a diagnostic biomarker and potential therapeutic target for sepsis-induced intestinal injury.
Authors
- Yanling Chen
- Hui An
- Cui Li
- Rong Hai
- Junna He
- Mali Fang
Institutions
- China Aerospace Science and Industry Corporation (China) (CN)
- Xinjiang Medical University (CN)
- Fifth Affiliated Hospital of Xinjiang Medical University (CN)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- First People's Hospital of Chongqing (CN)
- Baoding People's Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12876-025-04474-x
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00