TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming
Together, our data enhance the understanding of how TGFβ1 and microglial TGFβ signaling regulate microglial reactivity, further highlighting the essential functions of TGFβ1 as a potentimmunoregulatory factor for microglia.
Authors
- Jannik Jahn (ORCID: https://orcid.org/0009-0001-7881-427X)
- Natascha Vidovic (ORCID: https://orcid.org/0000-0002-1426-7625)
- Susanne Wiemann
- Phani Sankar Potru (ORCID: https://orcid.org/0000-0002-3968-3852)
- Christopher Kalischer
- Björn Spittau
- Nele Lehmann
- Tamara Russ
- Nikolai Leander Rupp
Institutions
- Bielefeld University (DE)
- Hochschule Bielefeld (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1623643
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Universität Bielefeld