The anti-osteoporotic effect of puerarin on the femoral bone in rat models of osteoporosis: a systematic review and meta-analysis

Puerarin exhibits significant therapeutic potential for OP in rat models by increasing BMD, improving bone quality, and rebalancing bone metabolism in favor of formation, primarily through the inhibition of resorption. The optimal effect appears to be dose- and duration-dependent. Although these preclinical findings are promising, the clinical translation of puerarin requires validation through larger-scale, high-quality animal studies and subsequent clinical trials.