Metabolic profiling defines glioblastoma subtypes with distinct prognoses and therapeutic vulnerabilities
Our study defines three biologically and clinically relevant metabolic subtypes of IDH-wildtype GBM. This classification reveals distinct metabolic programs and therapeutic vulnerabilities, providing a framework for precision metabolism-targeted strategies in glioblastoma.
Authors
- Yiyun Yin (ORCID: https://orcid.org/0009-0008-8926-3638)
- Guan-Zhang Li
- Z Wang
- Mingchen Yu
- Di Wang (ORCID: https://orcid.org/0000-0002-8184-8833)
- Fan Wu
- Wen-Hua Fan
- Zheng Zhao
- Tao Jiang
- Wei Zhang
- You Zhai
- Chang-Qing Pan
Institutions
- Capital Medical University (CN)
- Chinese National Human Genome Center (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1093/neuonc/noaf294
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00