Serologic IL-18 increase with B-cell IL-18R loss characterizes selective IgA deficiency
Adult sIgAD is characterized by a blood-measurable endotype in which a systemic IL-18-centered soluble signature coexists with reduced IL-18 receptor expression and altered signaling programs in B cells. This IL-18-IL-18R axis aligns with ANA/ENA-associated immune dysregulation and an IgG-skewed class-switch profile, nominating IL-18-related mediators and B-cell IL-18R expression as candidate biomarkers and mechanistic targets in a subset of adults with sIgAD.
Authors
- Hildur Sigurgrímsdóttir (ORCID: https://orcid.org/0000-0002-2080-5709)
- Fannar Theódórs
- Andri Leó Lemarquis (ORCID: https://orcid.org/0000-0001-5165-0247)
- H Einarsdottir (ORCID: https://orcid.org/0000-0002-3591-0480)
- Ingileif Jónsdóttir (ORCID: https://orcid.org/0000-0001-8339-150X)
- Olov Ekwall
- Ida Karnsund
- Gudmundur Jorgensen
- Bjorn R. Ludviksson
Institutions
- Reykjavík University (IS)
- City Of Hope National Medical Center (US)
- deCODE Genetics (Iceland) (IS)
- University of Iceland (IS)
- National University Hospital of Iceland (IS)
- City of Hope (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1687720
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00