Clostridium butyricum extracellular vesicles remodel the transcriptional network of pyroptosis-related genes in LPS-stimulated macrophages
<i>C. butyricum</i> EVs remodel the pyroptosis-related regulatory network by modulating key genes such as <i>IL-6</i>, <i>P2rx7</i>, and <i>ZBP1</i>, suggesting their potential role in fine-tuning LPS-induced inflammatory responses in macrophages.
Authors
- Mohd Shafiq Aazmi (ORCID: https://orcid.org/0000-0003-4942-8457)
- Qingyu Zhang
- Kailun He
- Mohd Fakharul Zaman Raja Yahya
Institutions
- Zhejiang A & F University (CN)
- Jiyang College of Zhejiang A&F University (CN)
- Universiti Teknologi MARA System (MY)
- ZheJiang Institute For Food and Drug Control (CN)
- Universiti Teknologi MARA (MY)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1686347
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Universiti Teknologi MARA
- Department of Education of Zhejiang Province
- Natural Science Foundation of Zhejiang Province