The Effect of Preeclampsia on the Cell Adhesion, Migration, and Proliferation Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells

The study concludes that MSCs derived from preeclampsia cord show decreased adhesion, migration, and proliferation capabilities compared to normal hUC-MSCs. These findings show that pregnancy complications can influence the biological properties of perinatal stem cells. However, further research is necessary to investigate the underlying mechanisms via which preeclampsia affects the proliferative potential of stem cells, and to identify strategies to increase the proliferation rates of these cells.

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Publication Details

Journal
Cureus
Published
2026-01-04
DOI
https://doi.org/10.7759/cureus.100783
Primary Topic
Pregnancy and preeclampsia studies
Type
article
Field-Weighted Citation Impact
0.00
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article

The Effect of Preeclampsia on the Cell Adhesion, Migration, and Proliferation Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Nabila Rasheed, Syeda Saima Razzaq, Anum Siraj, Jasmeet Kaur et al.
Cureus
Pregnancy and preeclampsia studies
article

The Effect of Preeclampsia on the Cell Adhesion, Migration, and Proliferation Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Nabila Rasheed, Syeda Saima Razzaq, Anum Siraj, Jasmeet Kaur, Kanwal Haneef, Arhum Mustajab, Nisha Zahid
article en

Abstract

The study concludes that MSCs derived from preeclampsia cord show decreased adhesion, migration, and proliferation capabilities compared to normal hUC-MSCs. These findings show that pregnancy complications can influence the biological properties of perinatal stem cells. However, further research is necessary to investigate the underlying mechanisms via which preeclampsia affects the proliferative potential of stem cells, and to identify strategies to increase the proliferation rates of these cells.

CureusVol. 18(1)
University of Karachi (PK), University Hospitals of Derby and Burton NHS Foundation Trust (GB), Andalusian Centre for Nanomedicine and Biotechnology (ES), Instituto de Investigación Biomédica de Málaga (ES), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 98%
Pregnancy and preeclampsia studies
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