Establishment of a Patient‐Derived Xenograft Model of a Testicular Yolk Sac Tumor
We have established a highly stable and reproducible patient derived xenograft model that exclusively and robustly retains the morphological, functional, and proliferative characteristics of human yolk sac tumor of the testis. This model might provide an invaluable in vivo platform for accelerating the discovery and validation of novel therapeutic strategies for this aggressive malignancy, with the ultimate aim of improving the prognosis for affected patients.
Authors
- Taku Naiki
- Satoru Takahashi (ORCID: https://orcid.org/0000-0002-8139-8158)
- Toshiharu Morikawa (ORCID: https://orcid.org/0009-0006-4430-0277)
- Takashi Nagai (ORCID: https://orcid.org/0000-0002-9635-4553)
- Nobuhiko Shimizu (ORCID: https://orcid.org/0000-0001-7280-2481)
- Masakazu Gonda (ORCID: https://orcid.org/0009-0002-9514-1561)
- Yukihiro Umemoto (ORCID: https://orcid.org/0000-0003-0692-2914)
- Toshiki Etani (ORCID: https://orcid.org/0000-0002-2841-7006)
- Aya Naiki‐Ito
- Yosuke Sugiyama (ORCID: https://orcid.org/0000-0001-8436-5872)
- T. Yasui
- Maria Aoki
- Daiki Ishikawa (ORCID: https://orcid.org/0009-0007-7975-2983)
Institutions
- Nagoya City University (JP)
- Nagoya City University Hospital (JP)
- Nagoya Medical Center (JP)
Publication Details
- Journal
- Pathology International
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1111/pin.70079
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science