SP1 and ELAVL1 cooperatively regulate ALOX15-mediated ferroptosis in an OGD/R-Induced SK-N-SH cell model of cerebral infarction

SP1 and ELAVL1 regulated ALOX15 to drive OGD/R-induced SK-N-SH cell injury and ferroptosis. These findings highlight the SP1/ELAVL1-ALOX15 axis as a potential therapeutic target for mitigating brain injury in CI, providing a translational basis for future interventions.

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Publication Details

Journal
Neurological Research
Published
2026-01-04
DOI
https://doi.org/10.1080/01616412.2025.2611334
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

SP1 and ELAVL1 cooperatively regulate ALOX15-mediated ferroptosis in an OGD/R-Induced SK-N-SH cell model of cerebral infarction

Rongbo Zhang, You Wu, Shunli Liang, Linsheng Xu et al.
Neurological Research
Ferroptosis and cancer prognosis
article

SP1 and ELAVL1 cooperatively regulate ALOX15-mediated ferroptosis in an OGD/R-Induced SK-N-SH cell model of cerebral infarction

Rongbo Zhang, You Wu, Shunli Liang, Linsheng Xu, Fangping Xie
article en

Abstract

SP1 and ELAVL1 regulated ALOX15 to drive OGD/R-induced SK-N-SH cell injury and ferroptosis. These findings highlight the SP1/ELAVL1-ALOX15 axis as a potential therapeutic target for mitigating brain injury in CI, providing a translational basis for future interventions.

Neurological Research
Zhejiang Chinese Medical University (CN), Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 98%
Ferroptosis and cancer prognosis
DOISourceOpenAlex
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