Regulatory RNA Ern0160 controls Enterococcus faecium virulence through direct modulation of expression of LysM domain-containing proteins
Our findings suggest that Ern0160 contributes to a regulatory network that modulates E. faecium colonization and infection by targeting genes involved in antimicrobial response and virulence. This study highlights the potential of regulatory RNAs such as Ern0160 to shape the pathogenic behavior of a multi-drug resistant and clinically significant bacterium.
Authors
- Vincent Cattoir (ORCID: https://orcid.org/0000-0003-4026-9912)
- Svetlana Chabelskaya (ORCID: https://orcid.org/0000-0002-9372-9356)
- Kevin Arnould
- François Guérin (ORCID: https://orcid.org/0000-0001-6821-3131)
- Charlotte Michaux (ORCID: https://orcid.org/0000-0003-1089-7846)
- Loren Dejoies
- Valérie Bordeau (ORCID: https://orcid.org/0000-0003-1137-1053)
- Sophie Reissier (ORCID: https://orcid.org/0009-0009-2806-4739)
- Killian Le Neindre (ORCID: https://orcid.org/0000-0003-1323-8715)
- Brice Felden
Institutions
- Inserm (FR)
- CNR de la Résistance aux Antibiotiques (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Bacterial RNAs & Medicine (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- BMC Genomics
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12864-025-12464-2
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00