The Identification of LA-tumor associated macrophages in immune modulation via amyloid-beta precursor protein/CD74 signal pathway in gastric cancer: a predictive module and machine learning
LA-TAM plays a key role in immune suppression and metabolic regulation in GC. Its key genes form a high-precision prognosis model, and endothelial cell-expressed APP may promote immune evasion by enhancing macrophage PD-1 expression, suggesting a potential target for immunotherapy.
Authors
- Jianpeng Wang (ORCID: https://orcid.org/0000-0002-7721-0896)
- Zhi-Jian Wei
- Ying Dai
- Zi-Ning Wang
- Chen-Chen An
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fonc.2025.1752562
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00