Saliva and blood miRNAs as complementary biomarkers for esophageal cancer detection

Circulating miRNAs show strong potential as liquid biopsy biomarkers for the non-invasive diagnosis of esophageal cancer. While saliva-derived miRNAs exhibit higher sensitivity, blood-derived miRNAs provide greater specificity. These findings indicate the need for further validation and standardization of miRNA-based assays to facilitate their integration into clinical practice for early detection of esophageal cancer.