Declining insulin sensitivity is a key pathological contributor to dysglycemia: a longitudinal validation study in the Korean genome and epidemiology study
Declining IS, independent of BCF, is associated with progression to T2D in lean Koreans. Preserving IS through lifestyle interventions is crucial for diabetes prevention, particularly in those with low BCF. Insulin resistance, β-cell function, disposition index, oral glucose tolerance test, body mass index.
Authors
- Arthur Sherman (ORCID: https://orcid.org/0000-0002-8372-5941)
- Myungsoo Im (ORCID: https://orcid.org/0009-0009-2758-9461)
- Y. K. Kim
- Yeong Jin Kim (ORCID: https://orcid.org/0000-0002-0057-4974)
- Jinmi Kim (ORCID: https://orcid.org/0000-0002-6715-0447)
- Doohwa Kim (ORCID: https://orcid.org/0009-0001-9289-355X)
- Joon Ha (ORCID: https://orcid.org/0000-0003-4173-2534)
- Seung Hyun Kim (ORCID: https://orcid.org/0000-0001-9644-9598)
- Hyuk Kang
- Minsoo Kim (ORCID: https://orcid.org/0009-0008-5081-2935)
- In Joo Kim
- Stephane T. Chung
- Soree Ryang
Institutions
- Howard University (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Pusan National University Hospital (KR)
- Advanced Analysis Center (JP)
- National Institute for Mathematical Sciences (KR)
- Pusan National University (KR)
- Korea Institute of Science & Technology Information (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fendo.2025.1726006
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Korea Disease Control and Prevention Agency
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Busan Metropolitan City
- Ministry of Science and ICT, South Korea
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases