Anti-interferon-α antibodies and HBsAg seroclearance during peginterferon-α therapy in chronic hepatitis B
CHB patients with lower baseline HBsAg or younger age achieved higher HBsAg clearance within 24 weeks. An early and pronounced rise in anti-IFNα IgM was associated with poor response to Peg-IFNα and may serve as an early warning marker.
Authors
- Shifang Peng (ORCID: https://orcid.org/0000-0001-5923-4029)
- Ying Jiang
- Da Cheng
- Wenting Peng
- Feilan Yang
- Lei Fu
- Chuan Jiang
- Jinqing Liu
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1016/j.ijid.2026.108370
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China