Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes
Overall, our study reveals major phenotypic and metabolic disturbances of circulating and tumor-infiltrating iNKT cells in melanoma, with clinical impacts. By unveiling new key features and skewing details on iNKT cells in melanoma, our study paves the way for innovative combination strategies exploiting metabolic pathways and/or disturbed ICP profiles to overcome immune subversion and better harness the potential of iNKT cells for cancer immunotherapy.
Authors
- P. Saas
- Julie Charles
- Caroline Aspord (ORCID: https://orcid.org/0000-0002-4979-7044)
- Emmanuelle Degeorges
- Pauline Girard
- F De Fraipont
- Camille Niveau
- Stéphane Mouret (ORCID: https://orcid.org/0000-0003-3880-973X)
- Mélanie Cettour-Cave
- Eleonora Sosa Cuevas
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Établissement Français du Sang (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1703754
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ligue Contre le Cancer
- Groupement des Entreprises Françaises dans la lutte contre le Cancer