Protocol for a review of statistical methods used to estimate risk ratios and risk differences in parallel cluster randomised trials

This review will provide the first detailed description of how risk ratios and risk differences are currently estimated and reported in cluster randomised trials. The findings will inform the development of methodological guidance and help identify gaps in reporting and implementation. This is particularly important as interest grows in improving estimand specification and the clarity of statistical analysis plans.

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Publication Details

Journal
Trials
Published
2026-01-05
DOI
https://doi.org/10.1186/s13063-025-09395-4
Primary Topic
Advanced Causal Inference Techniques
Type
article
Field-Weighted Citation Impact
0.00
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article

Protocol for a review of statistical methods used to estimate risk ratios and risk differences in parallel cluster randomised trials

Julia F Shaw, Karla Hemming, Sam Watson, Monica Taljaard et al.
Trials
Advanced Causal Inference Techniques
article

Protocol for a review of statistical methods used to estimate risk ratios and risk differences in parallel cluster randomised trials

Julia F Shaw, Karla Hemming, Sam Watson, Monica Taljaard, Jack A. Hall, Jon Bishop, Yixin Wang
article en

Abstract

This review will provide the first detailed description of how risk ratios and risk differences are currently estimated and reported in cluster randomised trials. The findings will inform the development of methodological guidance and help identify gaps in reporting and implementation. This is particularly important as interest grows in improving estimand specification and the clarity of statistical analysis plans.

TrialsVol. 27(1)
University of Ottawa (CA), Ottawa Hospital (CA), Cancer Research UK Clinical Trials Unit (GB), University of Birmingham (GB)
No poverty
Openalex Percentile: Top 97%
Advanced Causal Inference Techniques
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Protocol for a review of statistical methods used to estimate risk ratios and risk differences in parallel cluster randomised trials — Julia F Shaw, Karla Hemming, et al. · Trials (2026) | TGRS Research Map | TGRS