Protocol for a review of statistical methods used to estimate risk ratios and risk differences in parallel cluster randomised trials
This review will provide the first detailed description of how risk ratios and risk differences are currently estimated and reported in cluster randomised trials. The findings will inform the development of methodological guidance and help identify gaps in reporting and implementation. This is particularly important as interest grows in improving estimand specification and the clarity of statistical analysis plans.
Authors
- Julia F Shaw (ORCID: https://orcid.org/0000-0002-9768-1177)
- Karla Hemming (ORCID: https://orcid.org/0000-0002-2226-6550)
- Sam Watson (ORCID: https://orcid.org/0000-0002-8972-769X)
- Monica Taljaard
- Jack A. Hall
- Jon Bishop
- Yixin Wang
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Cancer Research UK Clinical Trials Unit (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Trials
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s13063-025-09395-4
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00