Exposure of in vitro maturing pig oocytes to exogenous interleukin-6 is associated with transcriptomic differences in the resulting blastocysts, with enrichment of developmental signaling pathways
Blastocysts derived from oocytes matured <i>in vitro</i> with 100 ng/mL of IL-6 exhibited differences in activity in several immune-related and lipid metabolism pathways through the overexpression of specific genes associated with cell proliferation, embryo development, and apoptosis reduction. These findings provide insights consistent with a role of IL-6 during porcine IVM and its association with oocyte developmental competence.
Authors
- Rodriguez-Martinez Heriberto
- Manuela Garcia-Canovas (ORCID: https://orcid.org/0000-0001-9317-0188)
- Inmaculada Parrilla (ORCID: https://orcid.org/0000-0002-5121-758X)
- Emilio Arsenio Martinez (ORCID: https://orcid.org/0000-0003-1260-9721)
- Cristina Cuello (ORCID: https://orcid.org/0000-0002-6202-5946)
- Alejandro Gonzalez‐Plaza (ORCID: https://orcid.org/0000-0003-2175-4904)
- Adelina López-Jara (ORCID: https://orcid.org/0009-0004-1614-8066)
- Maria A. Gil
Institutions
- Linköping University (SE)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fvets.2025.1716588
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Svenska Forskningsrådet Formas
- Vetenskapsrådet
- Agencia Estatal de Investigación