Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity
Our study characterised the consequences of Mecp2 loss in parvalbumin interneurons on amygdala microcircuit function and connectivity within the prefrontal cortex‒amygdala‒hippocampus triad. It also provided evidence that supports and complements previous findings on the role of interneurons in the functional deficits observed in Mecp2 knockout animal models.
Authors
- Teemu Aitta‐aho (ORCID: https://orcid.org/0000-0001-9332-3340)
- Svetlana M. Molchanova (ORCID: https://orcid.org/0000-0002-4061-4563)
- Bojana Kokinovic (ORCID: https://orcid.org/0000-0002-7916-693X)
- Maria Ryazantseva (ORCID: https://orcid.org/0000-0002-8201-817X)
- Joni Haikonen (ORCID: https://orcid.org/0000-0003-2432-0837)
- Sari Lauri
- Maj Liiwand
Institutions
- University of Helsinki (FI)
- Helsinki Institute of Physics (FI)
Publication Details
- Journal
- Molecular Autism
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s13229-025-00699-5
- Citations
- 1
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 30.93