Functional pancreatic neuroendocrine tumors predominantly presenting with hypercalcemia: a case report

Functional pancreatic neuroendocrine tumors (F-PNETs) that secrete parathyroid hormone-related protein (PTHrP) and cause hypercalcemia are extremely rare. This report details a 10-year course of a patient with pancreatic neuroendocrine tumor (PNET) and recurrent life-threatening hypercalcemia. Moreover, it comprehensively describes the evolution and management of hypercalcemia in this case, aiming to offer valuable insights for clinical diagnosis and treatment.