Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

This study demonstrates that LIPUS exerts an analgesic effect by targeting Panx1 in Schwann cells of the peripheral nervous system, thereby ameliorating neuroinflammation and providing sustained relief from TNP.

Authors

W Zhang
Haicheng Wang (ORCID: https://orcid.org/0000-0002-8238-8728)
Yao Liu (ORCID: https://orcid.org/0000-0001-5572-723X)
Shuyu Xu
Qingguo Pei
Xue Han

Institutions

Tongji University (CN)
Shanghai Stomatological Hospital (CN)

Publication Details

Journal: Frontiers in Immunology
Published: 2026-01-05
DOI: https://doi.org/10.3389/fimmu.2025.1712759
Primary Topic: Pain Mechanisms and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

W Zhang, Haicheng Wang, Yao Liu, Shuyu Xu et al.

Jan 5, 2026

Frontiers in Immunology

Pain Mechanisms and Treatments

article

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

W Zhang, Haicheng Wang, Yao Liu, Shuyu Xu, Qingguo Pei, Xue Han

January 5, 2026article en

Abstract

Frontiers in ImmunologyVol. 16

Tongji University (CN), Shanghai Stomatological Hospital (CN)

Good health and well-being

Openalex Percentile: Top 98%

Pain Mechanisms and Treatments

DOI Open Access PDF OpenAlex

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Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel — W Zhang, Haicheng Wang, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS