Safety and efficacy of preoperative chemotherapy for obstructive colon cancer with endoscopic stenting: SUCCEED study

This is a prospective, multicenter, single-arm Phase II trial involving patients with clinical stage II or III obstructive colon cancer. Eligible patients undergo successful SEMS placement followed by two cycles of CAPOX chemotherapy prior to elective surgery. The primary endpoint is the incidence of severe perioperative complications, defined as a composite of stent-related adverse events and Clavien - Dindo Grade III or higher postoperative complications. Secondary endpoints include chemotherapy-related adverse events, pathological response, and 2-year relapse-free survival. A total of 75 patients are planned for enrollment across 16 hospitals in Japan over 1.5 years. The study is registered in the Japan Registry of Clinical Trials (jRCTs051240077).

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Publication Details

Journal
Future Oncology
Published
2026-01-04
DOI
https://doi.org/10.1080/14796694.2025.2610466
Primary Topic
Colorectal Cancer Surgical Treatments
Type
article
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article

Safety and efficacy of preoperative chemotherapy for obstructive colon cancer with endoscopic stenting: SUCCEED study

Kentaro Ueno, Takehito Yamamoto, Kenji Kawada, J Matsubara et al.
Future Oncology
Colorectal Cancer Surgical Treatments
article

Safety and efficacy of preoperative chemotherapy for obstructive colon cancer with endoscopic stenting: SUCCEED study

Kentaro Ueno, Takehito Yamamoto, Kenji Kawada, J Matsubara, Yuki Nakanishi, Satoshi Nagayama, Koya Hida, Kenjiro Hirai, Kazutaka Obama, Nobuaki Hoshino, Rei Mizuno, Daisuke Ito, Yoshinori Hirasaki, Tomoaki Okada, Ryosuke Mizuno, Ryo Matsusue, Yoshiro Musha Kiyoshi Itatani, Ryo Takahashi, Ben Sasaki, Teppei Murakami, Keita Hanada, Takamasa Yamamoto, Ryosuke Okamura, Nobu Oshima
article en

Abstract

This is a prospective, multicenter, single-arm Phase II trial involving patients with clinical stage II or III obstructive colon cancer. Eligible patients undergo successful SEMS placement followed by two cycles of CAPOX chemotherapy prior to elective surgery. The primary endpoint is the incidence of severe perioperative complications, defined as a composite of stent-related adverse events and Clavien - Dindo Grade III or higher postoperative complications. Secondary endpoints include chemotherapy-related adverse events, pathological response, and 2-year relapse-free survival. A total of 75 patients are planned for enrollment across 16 hospitals in Japan over 1.5 years. The study is registered in the Japan Registry of Clinical Trials (jRCTs051240077).

Future OncologyVol. 22(3)
Kyoto University (JP), Tenri Hospital (JP), Kyoto Medical Center (JP), Kurashiki Central Hospital (JP), Fukui Red Cross Hospital (JP), Rakuwakai Otowa Hospital (JP), Suita Tokushukai Hospital (JP), Kobe City Nishi-Kobe Medical Center (JP), Otsu Red Cross Hospital (JP), Kyoto Katsura Hospital (JP), Kobe City Medical Center West Hospital (JP), Kyoto University Hospital (JP), Osaka Red Cross Hospital (JP), Japanese Red Cross Society Wakayama Medical Center (JP), Shiga Medical Center (JP), Kitano Hospital (JP), Kobe City Medical Center General Hospital (JP)
Good health and well-being
Openalex Percentile: Top 98%
Colorectal Cancer Surgical Treatments
DOISourceOpenAlex
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