Case Report: A case of cervical burkitt lymphoma and literature review

Primary cervical Burkitt's lymphoma (BL) is an extremely rare malignancy. This report describes the case of a 55-year-old woman admitted to the hospital with irregular vaginal bleeding. Histologically, the tumor cells demonstrated infiltrative growth, relatively uniform basophilic cytoplasm. Immunohistochemical analysis revealed positivity for B-cell markers (CD20, CD79α, etc.), with MYC expression in approximately 80% of cells, fluorescence <i>in situ</i> hybridization staining showed positivity for MYC translocation and molecular testing confirmed IG rearrangement. The diagnosis of Burkitt's lymphoma is based on its distinctive histological morphology in combination with immunohistochemistry and molecular testing.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-05
DOI
https://doi.org/10.3389/fonc.2025.1696219
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Case Report: A case of cervical burkitt lymphoma and literature review

Sen Miao, Hua Hao, Yue Bai
Frontiers in Oncology
Lymphoma Diagnosis and Treatment
article

Case Report: A case of cervical burkitt lymphoma and literature review

Sen Miao, Hua Hao, Yue Bai
article en

Abstract

Primary cervical Burkitt's lymphoma (BL) is an extremely rare malignancy. This report describes the case of a 55-year-old woman admitted to the hospital with irregular vaginal bleeding. Histologically, the tumor cells demonstrated infiltrative growth, relatively uniform basophilic cytoplasm. Immunohistochemical analysis revealed positivity for B-cell markers (CD20, CD79α, etc.), with MYC expression in approximately 80% of cells, fluorescence <i>in situ</i> hybridization staining showed positivity for MYC translocation and molecular testing confirmed IG rearrangement. The diagnosis of Burkitt's lymphoma is based on its distinctive histological morphology in combination with immunohistochemistry and molecular testing.

Frontiers in OncologyVol. 15
Affiliated Hospital of Jining Medical University (CN), Yangpu Hospital of Tongji University (CN)
Shanghai Municipal Health Commission, Tongji University
Good health and well-being
Openalex Percentile: Top 98%
Lymphoma Diagnosis and Treatment
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