The metabolic-immune interface of obesity in Covid-19: a role for angiotensin ii and inflammatory cytokines
Obesity exacerbates COVID-19 severity through RAAS imbalance and, amplified inflammatory responses. Ang II and pro-inflammatory cytokines may serve as early predictive biomarkers of disease progression in obese individuals, highlighting the metabolic-immune interface as a critical determinant of COVID-19 outcomes.
Authors
- Danilo Bretas de Oliveira (ORCID: https://orcid.org/0000-0002-8695-8740)
- Marcelo Henrique Fernandes Ottoni (ORCID: https://orcid.org/0000-0002-2333-2775)
- Etel Rocha Vieira
- Evelin Capellari Cárnio (ORCID: https://orcid.org/0000-0002-8735-4252)
- Juliane Duarte Santos (ORCID: https://orcid.org/0000-0002-4153-7731)
- Karine Beatriz Costa (ORCID: https://orcid.org/0000-0002-3383-3995)
- Marina Luiza Baêta Costa (ORCID: https://orcid.org/0009-0000-9175-8180)
- Cintia Maria Rodrigues
- Daniel Macedo
- Bruna Carolina Chaves Garcia
- Vívian Gonzalez Figueiredo
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1729494
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade de São Paulo