The role of PLOD family genes in liver hepatocellular carcinoma: from mechanisms to therapeutic potential
Our study demonstrates that PLOD1, PLOD2, and PLOD3 are significantly upregulated in LIHC and correlate with poor prognosis. The PLOD genes may serve as valuable biomarkers for diagnosis and prognosis in LIHC. Moreover, targeting PLOD genes could provide new therapeutic strategies to hinder tumor progression and metastasis in liver cancer.
Authors
- Hongjian Cai (ORCID: https://orcid.org/0000-0002-0556-3182)
- J. Chen (ORCID: https://orcid.org/0000-0003-0451-2292)
- Huaguo Feng
- Guangwen Hu
- Yinghui Bi
Institutions
- Qingdao University (CN)
- Qilu University of Technology (CN)
- Chongqing University (CN)
- Qingdao Municipal Hospital (CN)
- Jiangjin Central Hospital (CN)
- Qingdao Eighth People's Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12885-025-15472-3
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00