Autonomic nervous system maturation in preterm neonates: Correlation with gestational and postmenstrual age (ProMote)
This study demonstrates that advancing gestational age is associated with greater parasympathetic modulation and more balanced sympathovagal control. Birth gestational age is a strong determinant of autonomic nervous system development at 35-36 weeks postmenstrual age. These findings highlight the importance of stratifying by gestational age in HRV studies and may inform neurodevelopmental monitoring and NICU care strategies.
Authors
- Theano Kokkinaki (ORCID: https://orcid.org/0000-0002-5136-4619)
- Aristeidis Petrakis
- Theano Roumeliotaki (ORCID: https://orcid.org/0000-0002-5044-983X)
- Νicole Anagnostatou
- Έlena Vakonaki
- Ιoannis Kyprakis
- Αristidis Tsatsakis
- Haridimos Kondylakis
- Μaria Markodimitraki
- Εleftheria Hatzidaki
- Μanolis Tzatzarakis
Institutions
- University of Crete (GR)
- Sechenov University (RU)
- FORTH Institute of Applied and Computational Mathematics (GR)
- University Hospital of Heraklion (GR)
- Universidad Ecotec (EC)
- Crete University Press (GR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1371/journal.pone.0339681
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00