Towards Understanding the Drivers of Antibody-Antigen Binding

Antibodies represent an important and expanding class of therapeutics for a range of diseases including infectious diseases, cancers, and autoimmune disorders. Enhancing our fundamental understanding of what drives antibody-antigen interactions is critical to our enhancing our ability to modulate these interactions. This work presents a systematic, physics-based study of antibody-antigen interfaces, and identifies key drivers of binding.