Effect of gender-affirming treatments on depression and anxiety symptoms in transgender people: a retrospective cohort study

Gender-affirming medical treatments alone may not entirely resolve the mental health difficulties faced by transgender individuals. Future research needs to better elucidate the impacts of persistent psychosocial challenges such as discrimination and rejection, as well as potential treatment complications. The treatment-seeking nature of this cohort, coupled with baseline psychiatric interventions, may have obscured significant correlations. While gender-affirming treatments can enhance gender congruence, our findings highlight the importance of holistic approaches to strengthen adaptive buffering mechanisms throughout the gender transition process.