What does not kill you makes you Weaker!
Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells that survived either immunotherapy- or irradiation-treatment rely on to proliferate. Therefore, they discovered the persister cells´ Achilles heel for future treatments with BH3-mimetics [2].
Authors
- Francesca Maremonti (ORCID: https://orcid.org/0000-0002-7670-2055)
- Andreas Linkermann
Institutions
- Albert Einstein College of Medicine (US)
- Heidelberg University (DE)
- University Medical Centre Mannheim (DE)
- University Hospital Carl Gustav Carus (DE)
Publication Details
- Journal
- Cell Death and Differentiation
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1038/s41418-025-01658-6
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00